A student nurse is preparing to administer the client’s first dose of tetracycline while the charge nurse observes. What statement by the student nurse prompts the charge nurse to provide further teaching? Select all that apply.

  • “Tetracycline may be given with grapefruit juice.”
  • “After taking tetracycline, the client should wait two hours before eating.”
  • “It should be given with caution in clients with liver or renal dysfunction.”
  • “The client may have an antacid along with the tetracycline if it causes GI upset.”
  • “It should be taken on an empty stomach at least one hour before meals with a glass of milk.”
Numbers 4 and 5 are correct.
Antacids interfere with absorption of tetracycline, along with food, milk, and milk products. Aluminum, calcium, and magnesium decrease absorption of the drug. It may be taken on an empty stomach with another liquid besides milk. Grapefruit juice does not interfere with tetracycline, which should be given on an empty stomach at least one hour before meals or two hours afterward. Tetracycline should be given with caution in clients with renal or liver dysfunction, and blood panels should be monitored.