The nurse is caring for a client receiving pantoprazole. The nurse understands that long-term use of proton pump inhibitors increases the risk of which serious side effects?

Select all that apply.
  • nausea
  • depression
  • constipation
  • rhabdomyolysis
  • long bone fractures
Numbers 2, 4, and 5 are correct.
Serious side effects caused by long-term use of proton pump inhibitors include depression, rhabdomyolysis, and long bone fractures. Serious side effects are more likely at higher doses. Nausea and constipation are minor side effects.