The nurse is preparing to administer the first dose of intravenous immunoglobulin (IVIG) to a 50-year-old female adult client admitted to the hospital with Guillain-Barre syndrome. Which nursing intervention is appropriate regarding administration?

  1. administer IVIG transfusion at a constant rate
  2. monitor vital signs within 15 minutes prior to administration and within 30 minutes after starting the infusion
  3. administer IVIG at room temperature
  4. should chills occur during the infusion, continue the infusion and provide the client with a blanket
Number 3 is correct.
Rationale: IVIG is stored under refrigeration yet should be administered at room temperature, typically within 30 minutes of removal from cold storage. The IVIG infusion rate is slow at first and increased gradually every 15 to 30 minutes as tolerated by the client until the maximum infusion rate may be administered. Vital signs should be monitored 15 minutes prior to administration, 15 minutes after initiation of infusion, and at every rate change. Chills, considered an adverse reaction to IVIG, warrant stopping the infusion.