A nurse is preparing to talk about hormone replacement therapy (HRT) to a group of women at a women’s fair at the local hospital. Which statements regarding HRT are correct?

Select all that apply.
  1. HRT decreases the risk of breast cancer.
  2. HRT decreases the risk of stroke in postmenopausal women.
  3. HRT lowers the risk of bone fractures caused by osteoporosis.
  4. HRT increases the risk of bone fractures caused by osteoporosis.
  5. HRT decreases the risk of coronary artery disease (CAD) in women who do not smoke.
Number 3 is correct.
Rationale: HRT lowers the risk of bone fractures caused by osteoporosis but increases the risk of breast cancer and stroke. HRT increases the risk of coronary artery disease in all women, especially smokers, who already increase their risk of CAD by smoking.