A client newly diagnosed with type 1 diabetes mellitus asks the nurse why it is important to rotate insulin injection sites. The nurse explains this is done to avoid

  1. tissue scarring.
  2. insulin resistance.
  3. localized edema.
  4. lipodystrophy.
Number 4 is correct.
Rationale: Insulin lipodystrophy can occur if insulin is injected repeatedly into the same area of skin. This leads to formations of fat deposit that can cause unpredictable absorption of insulin at the site. While localized edema can occur at the injection site, this is not harmful and will quickly resolve. Tissue scarring will not occur in fatty tissue. Insulin resistance is a precursor to the development of type 2 diabetes.