Rationale: A deficiency in clotting factor VIII would lead to a diagnosis of hemophilia A, a disorder that causes increased bleeding due to a lack of an essential blood clotting protein. It is more commonly seen in males and is caused by an X-linked recessive trait. Pernicious anemia usually occurs later in life and is a type of anemia that can be corrected with B12. Sickle cell and Tay-Sachs are also inherited diseases, but manifest with different symptoms from hemophilia.
